In the settlement of Meronas, the priest Cristoforo Buondelmonti mentions at the beginning of the 15th century the dynamic presence of the Kallergis family who seems to have completely controlled the area and rallied the orthodox population against the Venetians. In the center of the settlement, the church of Panagia is preserved to this day. It was originally built as a double-vaulted arch. Later, another nave, similar to the north, was added to the south side.
The two original aisles are recorded with excellent quality frescoes from the middle of the 14th century which differ from the average level of artistic activity on the island and express the conservative, academic tendencies of Constantinople. This is the work of painters who were transferred from the artistic centers of Byzantium and strongly influenced the development of monumental painting in Crete. The church also preserves an excellent portable icon of Panagia Odegetria, from the middle of the 14th century, a work clearly from Constantinople, which can also be connected to the sponsors.